VLS RETATRUTIDE

HOW IT WORKS?

Retatrutide is a medication designed primarily for weight management. It works by targeting certain receptors in the body to help control hunger and appetite, thereby aiding in weight loss.

VLS RETATRUTIDE for Weightloss

• Increased appetite suppression
• Retatrutide can help regulate insulin secretion and improve insulin sensitivity
• Improved metabolic health
• Improved long term weight management

FAQs

Q: What is VLS Retatrutide?

1. GLP-1 (glucagon-like peptide-1): This hormone helps regulate blood sugar levels and reduces appetite.
2. GIP (gastric inhibitory polypeptide): It plays a role in insulin secretion and may help reduce appetite.
3. Glucagon: It helps regulate blood sugar and energy balance in the body.

Q: When should I not use VLS Retatrutide?

• Risk of Thyroid Tumors: Like other GLP-1 receptor agonists, retatrutide could increase the risk of developing thyroid tumors, including medullary thyroid cancer. People with a family history of MTC or MEN 2 are generally advised not to use drugs in this class.
• Gastrointestinal Side Effects: Retatrutide, like other similar medications, may cause gastrointestinal side effects such as nausea, vomiting, diarrhea, or constipation. Those with severe gastrointestinal conditions (e.g., gastroparesis, bowel obstruction) might experience worsened symptoms or complications.
• Risk of Hypoglycemia: While retatrutide has shown potential for controlling blood sugar in Type 2 diabetes, it is not intended for use in Type 1 diabetes. The medication may cause blood sugar to drop too low in people with Type 1 diabetes, potentially leading to dangerous hypoglycemic episodes.

Q: How should I use VLS Retatrutide?

• VLS Retatrutide is injected under the skin (subcutaneously) of your stomach (abdomen), thigh, or upper arm. Do not inject VLS Retatrutide into a muscle (intramuscularly) or vein (intravenously).
• Use VLS Retatrutide 1 time each week, on the same day each week, at any time of the day.
• You may change the day of the week you use VLS Retatrutide as long as your last dose was given 2 or more days before.
• If you miss a dose of VLS Retatrutide, take the missed dose as soon as possible within 5 days after the missed dose. If more than 5 days have passed, skip the missed dose and take your next dose on the regularly scheduled day.
• VLS Retatrutide may be taken with or without food.
• Do not mix insulin and VLS Retatrutide together in the same injection.
• You may give an injection of VLS Retatrutide and insulin in the same body area (such as your stomach area), but not right next to each other.
• Change (rotate) your injection site with each injection. Do not use the same site for each injection.
• Check your blood sugar as your healthcare provider tells you to.
• Stay on your prescribed diet and exercise program while using VLS Retatrutide.
• Talk to your healthcare provider about how to prevent, recognize and manage low blood sugar(hypoglycemia), high blood sugar (hyperglycemia), and problems you have because of your diabetes.
• Your healthcare provider will check your diabetes with regular blood tests, including your blood sugar levels and your hemoglobin A1C.
• Do not share your VLS Retatrutide pen with other people, even if the needle has been changed. You may give other people a serious infection, or get a serious infection from them.
• Your dose of VLS Retatrutide and other diabetes medicines may need to change because of change in level of physical activity or exercise, weight gain or loss, increased stress, illness, change in diet, fever, trauma, infection, surgery or because of other medicines you take.
• If you take too much VLS Retatrutide, call your healthcare provider or go to the nearest hospital emergency room right away.

Q: What are the possible side effects of VLS Retatrutide?

• Nausea: A common side effect, especially when starting the medication. This tends to improve over time as the body adjusts.
• Vomiting: Some people may experience vomiting, particularly during the initial stages of treatment.
• Diarrhea or Constipation: These can occur, with some people experiencing one more than the other.
• Abdominal Pain: Stomach discomfort or pain is also reported by some users.

• While this is a desired effect for many, some people may experience it too strongly, leading to reduced food intake and potential issues like fatigue or weakness.

• Potential Risk: Similar to other GLP-1 receptor agonists, retatrutide may carry a risk of thyroid tumors, including medullary thyroid cancer (MTC), and a possible increased risk of developing certain types of thyroid conditions.
• Caution for those with a Family History: It is especially not recommended for people with a family history of MTC or multiple endocrine neoplasia syndrome type 2 (MEN 2).

• Symptoms: Severe abdominal pain, nausea, and vomiting could indicate pancreatitis. If this happens, the drug should be discontinued immediately, and medical attention sought.

• Dehydration Risk: If nausea, vomiting, or diarrhea are severe, dehydration could occur, which may lead to kidney problems. People with preexisting kidney conditions may need to be more cautious.

• This is more likely to occur if Retatrutide is used in combination with other diabetes medications that lower blood sugar, such as insulin or sulfonylureas.
• Symptoms: Shaking, sweating, dizziness, and confusion are signs of low blood sugar.

• Symptoms: Rash, itching, swelling, or difficulty breathing could indicate an allergic reaction. In severe cases, this could lead to anaphylaxis (a life-threatening reaction), though this is rare.

• Gallstones: There is a potential risk of developing gallstones, which could lead to pain in the upper abdomen, nausea, and vomiting.

Usage

Initial Dose Escalation Schedule

• Weeks 1 through 4: 2 mg subcutaneously once a week
• Weeks 5 through 8: 5 mg subcutaneously once a week
• Weeks 9 through 12: 8 mg subcutaneously once a week
• Weeks 13 through 16: 10 mg subcutaneously once a week

Maintenance Dose

• Week 17 and onward: 2.5 mg subcutaneously once a week

Dosing Considerations

• If dose escalation is not tolerated, consider delaying dose escalation for 4 weeks
• Do not increase dose if desired results are achieved at a lower dose, most people maintain at 10mg per week

Instructions

Step 1:

1. Wash your hands with soap and water.
2. Check the name and colored label of your pen, to make sure that it contains VLS Retatrutide. This is especially important if you take more than 1 type of medicine.
3. Pull off the pen cap.

Step 2:

1. Check that the VLS Retatrutide medicine in your pen is clear and colorless. Look through the pen window. If VLS Retatrutide looks cloudy or contains particles, do not use the pen.

Step 3:

1. Take a new needle, and tear off the paper tab.
2. Do not attach a new needle to your pen until you are ready to give your injection.

Step 4:

1. Push the needle straight onto the pen. Turn until it is on tight.

Step 5:

1. The needle is covered by 2 caps. You must remove both caps. If you forget to remove both caps, you will not inject any medicine.
2. Pull off the outer needle cap. Do not throw it away.

Step 6:

1. Pull off the inner needle cap and throw it away.

Step 7:

1. Check the VLS Retatrutide flow before the first injection with each new pen only.
2. Turn the dose selector until the dose counter shows the flow check symbol ▪▪▰

Step 8:

1. Hold the pen with the needle pointing up. Press and hold in the dose button until the dose counter shows 0. The 0 must line up with the dose pointer. A drop of VLS Retatrutide will appear at the needle tip.
2. If no drop appears, repeat Step 7 above as shown in Figure G and Figure H up to 6 times.
3. If there is still no drop, change the needle and repeat Step 7 as shown in Figure G and Figure H, 1 more time.

Do not use the pen if a drop of VLS Retatrutide still does not appear. Contact at vls-pen@protonmail.com.

Step 9:

Select your dose

1. Turn the dose selector until the dose counter stops and shows your 2 mg dose. The dashed line in the dose counter (┇) will guide you to 2 mg.
2. Always use the dose counter and the dose pointer to see that 2 mg has been selected. You will hear a “click” every time you turn the dose selector. Do not set the dose by counting the number of clicks you hear. Only doses of 2 mg can be selected with the dose selector.

Step 10:

To see how much VLS Retatrutide is left in your pen, use the dose counter:

1. Turn the dose selector until the dose counter stops.
2. If it shows 1, at least 1 mg is left in your pen. If the dose counter stops before 1 mg, there is not enoughVLS Retatrutide left for a full dose of 1 mg.

If there is not enough VLS Retatrutide left in your pen for a full dose, do not use it. Use a new VLS Retatrutidepen.

Step 11:

Inject your dose

1. Choose your injection site and wipe the skin with an alcohol swab. Let the injection site dry before you inject your dose (See Figure K).

Step 12:

1. Insert the needle into your skin as your healthcare provider has shown you.
2. Make sure you can see the dose counter. Do not cover it with your fingers. This could stop the injection.

Step 13:

1. Press and hold down the dose button until the dose counter shows 0.
2. The 0 must line up with the dose pointer. You may then hear or feel a click.
3. Continue pressing the dose button while keeping the needle in your skin.

Step 14:

1. Count 6 seconds while keeping the dose button pressed.
2. If the needle is removed earlier, you may see a stream of VLS Retatrutide coming from the needle tip. If this happens, the full dose will not be delivered.

Step 15:

1. Remove the needle from your skin. You can then release the dose button.
2. If blood appears at the injection site, press lightly with a gauze pad or cotton ball.

Do not rub the area.

Step 16:

After your injection

1. Carefully remove the needle from the pen. Do not put the needle caps back on the needle to avoid needle sticks.

Step 17:

1. Place the needle in a sharps disposal container right away to reduce the risk of needle sticks.

Step 18:

1. Put the pen cap on your pen after each use to protect VLS Retatrutide from light.

Step 19:

1. If you do not have a sharps disposal container, follow a 1-handed needle recapping method. Carefully slip the needle into the outer needle cap. Dispose of the needle in a sharps disposal container as soon as possible.
2. Never try to put the inner needle cap back on the needle. Always remove the needle from your pen.
3. Always dispose of the needle after each injection.